<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:b9bf9d00-f4fb-4473-b55c-e4c0cd2c5a11,g:1ad0ea4b-cec0-4fe1-abbc-45514359efd4-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.kerostx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="kros-20250331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_cfd79627-4ae2-432b-894a-baa93facd7fd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_6deabd51-d873-4959-9ff9-538c0fe94839" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cfd79627-4ae2-432b-894a-baa93facd7fd" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_6deabd51-d873-4959-9ff9-538c0fe94839" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_07ed4c28-5f04-4654-9006-56cb8f52af93" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cfd79627-4ae2-432b-894a-baa93facd7fd" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_07ed4c28-5f04-4654-9006-56cb8f52af93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_8b375795-e5f0-4a92-a633-1f95f7617afe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cfd79627-4ae2-432b-894a-baa93facd7fd" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_8b375795-e5f0-4a92-a633-1f95f7617afe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_4979943a-d1e3-495e-8572-2f73b0f806a5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cfd79627-4ae2-432b-894a-baa93facd7fd" xlink:to="loc_us-gaap_AccountsPayableCurrent_4979943a-d1e3-495e-8572-2f73b0f806a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_9fdfb753-4569-4467-8c3c-0df219e43a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cfd79627-4ae2-432b-894a-baa93facd7fd" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_9fdfb753-4569-4467-8c3c-0df219e43a9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_8ce5a760-f937-45d7-a395-6df2818975e5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_94409a98-77c1-4336-a496-5699cb9b488c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_8ce5a760-f937-45d7-a395-6df2818975e5" xlink:to="loc_us-gaap_Liabilities_94409a98-77c1-4336-a496-5699cb9b488c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_140027e4-937c-4097-8224-0fa6d1a5dacb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_8ce5a760-f937-45d7-a395-6df2818975e5" xlink:to="loc_us-gaap_StockholdersEquity_140027e4-937c-4097-8224-0fa6d1a5dacb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_fd7a66a0-46c1-4f55-83df-8dce073930cf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_2ca59d14-0724-4629-9312-7f6d56fbcfca" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fd7a66a0-46c1-4f55-83df-8dce073930cf" xlink:to="loc_us-gaap_AssetsCurrent_2ca59d14-0724-4629-9312-7f6d56fbcfca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_95a2e257-33a3-4add-9697-96d484954a81" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fd7a66a0-46c1-4f55-83df-8dce073930cf" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_95a2e257-33a3-4add-9697-96d484954a81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ca04e58d-5010-4b6b-aac4-6f3ebd86665b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fd7a66a0-46c1-4f55-83df-8dce073930cf" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_ca04e58d-5010-4b6b-aac4-6f3ebd86665b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_8f79d350-dd41-4870-b327-3770ee165762" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fd7a66a0-46c1-4f55-83df-8dce073930cf" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_8f79d350-dd41-4870-b327-3770ee165762" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_b4220ead-06f5-4d8a-af8a-1e5093420673" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fd7a66a0-46c1-4f55-83df-8dce073930cf" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_b4220ead-06f5-4d8a-af8a-1e5093420673" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_54eb1936-8103-4576-ae92-95246a4f8e2f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_278c4346-022b-4b4b-9080-d53edcbbb68a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_54eb1936-8103-4576-ae92-95246a4f8e2f" xlink:to="loc_us-gaap_LiabilitiesCurrent_278c4346-022b-4b4b-9080-d53edcbbb68a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_fe51a6f1-fce6-458c-b4dc-9b1f1c5f8651" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_54eb1936-8103-4576-ae92-95246a4f8e2f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_fe51a6f1-fce6-458c-b4dc-9b1f1c5f8651" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_92fe625b-b374-4da9-95e5-8177353973f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_608054eb-4feb-429a-a8c5-aa8025039f65" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_92fe625b-b374-4da9-95e5-8177353973f1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_608054eb-4feb-429a-a8c5-aa8025039f65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_f502b42d-0127-42a4-a8b1-4201c70ecbf3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_92fe625b-b374-4da9-95e5-8177353973f1" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_f502b42d-0127-42a4-a8b1-4201c70ecbf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d88cf674-463f-48cf-8ba5-2fd6c05cb46d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_92fe625b-b374-4da9-95e5-8177353973f1" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_d88cf674-463f-48cf-8ba5-2fd6c05cb46d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7ddb7ad8-81b8-4da1-9659-c5311452a48e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_cc6eaf0a-8a71-42ca-9028-51d6ed8775f4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7ddb7ad8-81b8-4da1-9659-c5311452a48e" xlink:to="loc_us-gaap_PreferredStockValue_cc6eaf0a-8a71-42ca-9028-51d6ed8775f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_5e4c72d9-0492-42b4-939c-510d1b7c0f70" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7ddb7ad8-81b8-4da1-9659-c5311452a48e" xlink:to="loc_us-gaap_CommonStockValue_5e4c72d9-0492-42b4-939c-510d1b7c0f70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_2117abcc-a1f5-4e72-9cc3-49b8b54fa2d7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7ddb7ad8-81b8-4da1-9659-c5311452a48e" xlink:to="loc_us-gaap_AdditionalPaidInCapital_2117abcc-a1f5-4e72-9cc3-49b8b54fa2d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e693060b-774a-412b-b1f3-336ad28ae8f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7ddb7ad8-81b8-4da1-9659-c5311452a48e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e693060b-774a-412b-b1f3-336ad28ae8f9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="kros-20250331.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c2069cb0-9842-4f94-8507-98e71f5ae8cd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e09d2d0a-bdff-481e-a165-d9354aed8acf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c2069cb0-9842-4f94-8507-98e71f5ae8cd" xlink:to="loc_us-gaap_OperatingIncomeLoss_e09d2d0a-bdff-481e-a165-d9354aed8acf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_16cd53e0-6aeb-46a3-8d68-b6bcf5c6ad27" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c2069cb0-9842-4f94-8507-98e71f5ae8cd" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_16cd53e0-6aeb-46a3-8d68-b6bcf5c6ad27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5adda40b-6349-4977-a200-e141f08cc93f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_5537bf28-bddb-45c1-b4df-d09188d3c25d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_5adda40b-6349-4977-a200-e141f08cc93f" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_5537bf28-bddb-45c1-b4df-d09188d3c25d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_0524fbf8-542c-4e48-bb40-eed634b8e4d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_5adda40b-6349-4977-a200-e141f08cc93f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_0524fbf8-542c-4e48-bb40-eed634b8e4d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_26454446-d4bc-4191-878e-019979596316" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendIncomeOperating_d9ec9b7b-b0d3-4f80-8a5e-8441bec2df3f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_26454446-d4bc-4191-878e-019979596316" xlink:to="loc_us-gaap_DividendIncomeOperating_d9ec9b7b-b0d3-4f80-8a5e-8441bec2df3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_fe607550-1771-4721-9b2a-124c69cbebc1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_26454446-d4bc-4191-878e-019979596316" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_fe607550-1771-4721-9b2a-124c69cbebc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_d74ac240-5d86-4f2a-b2ed-06fbcf0861a6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_253798d5-e187-4d89-ad48-9e7668443d00" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_d74ac240-5d86-4f2a-b2ed-06fbcf0861a6" xlink:to="loc_us-gaap_OperatingExpenses_253798d5-e187-4d89-ad48-9e7668443d00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_776c4f81-a5bd-4713-b542-c2ee81a41dd7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_d74ac240-5d86-4f2a-b2ed-06fbcf0861a6" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_776c4f81-a5bd-4713-b542-c2ee81a41dd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_201d99f8-5cd2-4daf-811a-9c5287c9972c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_cee5089c-dd7c-4b4b-ba70-ba3bdc994108" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_201d99f8-5cd2-4daf-811a-9c5287c9972c" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_cee5089c-dd7c-4b4b-ba70-ba3bdc994108" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_262f60e5-5a52-46f4-8bcd-d76905b22f7d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_201d99f8-5cd2-4daf-811a-9c5287c9972c" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_262f60e5-5a52-46f4-8bcd-d76905b22f7d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="kros-20250331.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_8d20fbc7-6783-48f8-9f9a-68bca89c98e3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_20cb7391-acd7-48e1-a088-2e5bd9734ae0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_8d20fbc7-6783-48f8-9f9a-68bca89c98e3" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_20cb7391-acd7-48e1-a088-2e5bd9734ae0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_369bc60f-d107-4171-969d-7ef1e6603c08" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_8d20fbc7-6783-48f8-9f9a-68bca89c98e3" xlink:to="loc_us-gaap_RestrictedCash_369bc60f-d107-4171-969d-7ef1e6603c08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d90d79ae-c02e-4b8a-9c98-eb0f0ad82174" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_20f8b70c-97e5-41a4-8acf-77651e322b16" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d90d79ae-c02e-4b8a-9c98-eb0f0ad82174" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_20f8b70c-97e5-41a4-8acf-77651e322b16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_PaymentOfInitialPublicOfferingCosts_1417b56f-a42d-443b-baf7-be3bb35791cd" xlink:href="kros-20250331.xsd#kros_PaymentOfInitialPublicOfferingCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d90d79ae-c02e-4b8a-9c98-eb0f0ad82174" xlink:to="loc_kros_PaymentOfInitialPublicOfferingCosts_1417b56f-a42d-443b-baf7-be3bb35791cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_212200e7-96c1-4f80-bd2a-7cf947bf3fd5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d90d79ae-c02e-4b8a-9c98-eb0f0ad82174" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_212200e7-96c1-4f80-bd2a-7cf947bf3fd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1cbd23a2-8c33-4f3f-a84f-18871e28b918" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_238b3f16-f80d-4c17-98f7-d72463984690" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1cbd23a2-8c33-4f3f-a84f-18871e28b918" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_238b3f16-f80d-4c17-98f7-d72463984690" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_bc8a8724-eeae-4bb8-8b93-95132877ecc3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1cbd23a2-8c33-4f3f-a84f-18871e28b918" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_bc8a8724-eeae-4bb8-8b93-95132877ecc3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce41f733-0629-4b8a-9052-69449235b0d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1cbd23a2-8c33-4f3f-a84f-18871e28b918" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce41f733-0629-4b8a-9052-69449235b0d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_888e8c5b-81dc-450e-bc41-1d9e5fc78185" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_bd49e7eb-6f3c-42be-b9b7-f328e9fb4175" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_888e8c5b-81dc-450e-bc41-1d9e5fc78185" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_bd49e7eb-6f3c-42be-b9b7-f328e9fb4175" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_dcc64ce9-f44f-40e1-a94e-79917d54221d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_dcc64ce9-f44f-40e1-a94e-79917d54221d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_8ab8451a-8da1-435b-97a2-81cea2b1f9db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_ShareBasedCompensation_8ab8451a-8da1-435b-97a2-81cea2b1f9db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_c0061eb4-cfb3-416d-8f9a-e1339cb96a65" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_c0061eb4-cfb3-416d-8f9a-e1339cb96a65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_RightToUseAssetsAndOperatingLeaseLiabilities_223fa61e-b18e-42eb-8ee5-2472904f577b" xlink:href="kros-20250331.xsd#kros_RightToUseAssetsAndOperatingLeaseLiabilities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_kros_RightToUseAssetsAndOperatingLeaseLiabilities_223fa61e-b18e-42eb-8ee5-2472904f577b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_69ffefa3-e5de-48e9-9b69-d56209565bfa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_69ffefa3-e5de-48e9-9b69-d56209565bfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_39ca09d8-8439-4e3a-8754-5afce9869e00" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_39ca09d8-8439-4e3a-8754-5afce9869e00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_969c70ad-852b-4efa-a3aa-254de50f17f8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_969c70ad-852b-4efa-a3aa-254de50f17f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedTaxesPayable_71a95cba-779a-45fa-a86c-c7a0c6f5619a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedTaxesPayable"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedTaxesPayable_71a95cba-779a-45fa-a86c-c7a0c6f5619a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_ee746e1a-98c9-47ac-a16b-9bbe4116a5f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_Depreciation_ee746e1a-98c9-47ac-a16b-9bbe4116a5f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_d52fdf1a-0a6a-47f7-9f98-83853e5ce991" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_d52fdf1a-0a6a-47f7-9f98-83853e5ce991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b4904f1f-b12c-46e9-9c3c-cb700602343b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_NetIncomeLoss_b4904f1f-b12c-46e9-9c3c-cb700602343b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_7f39551f-d1d3-4a18-b8b6-58d072357def" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c7a28cb5-edb7-4167-8183-ad7ff089c78a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_7f39551f-d1d3-4a18-b8b6-58d072357def" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="kros-20250331.xsd#FAIRVALUEMEASUREMENTSScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_cb17c901-a809-49c2-9a06-9b01bd423268" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_5f3c4da5-0092-4d73-ad36-b579041cbce2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_cb17c901-a809-49c2-9a06-9b01bd423268" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_5f3c4da5-0092-4d73-ad36-b579041cbce2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/PREPAIDEXPENSESANDOTHERCURRENTASSETSScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="kros-20250331.xsd#PREPAIDEXPENSESANDOTHERCURRENTASSETSScheduleofPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/PREPAIDEXPENSESANDOTHERCURRENTASSETSScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_98707cd2-3306-42b0-8460-25bd757545b6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_us-gaap_PrepaidInsurance_98707cd2-3306-42b0-8460-25bd757545b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_PrepaidExternalManufacturingCostsCurrent_3424f500-aea3-4219-aee5-49c30f0cac07" xlink:href="kros-20250331.xsd#kros_PrepaidExternalManufacturingCostsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_kros_PrepaidExternalManufacturingCostsCurrent_3424f500-aea3-4219-aee5-49c30f0cac07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendAndInterestReceivable_b0014a6e-81c3-4301-a25c-58ae729b5017" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DividendAndInterestReceivable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_us-gaap_DividendAndInterestReceivable_b0014a6e-81c3-4301-a25c-58ae729b5017" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_e1597d89-bad3-4b39-a958-85b00924d1f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_us-gaap_OtherAssetsCurrent_e1597d89-bad3-4b39-a958-85b00924d1f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_PrepaidSubscriptionCurrent_47315eb0-8dd0-4ae8-b833-c55fcf2c1127" xlink:href="kros-20250331.xsd#kros_PrepaidSubscriptionCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_kros_PrepaidSubscriptionCurrent_47315eb0-8dd0-4ae8-b833-c55fcf2c1127" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_SalesTaxReceivableCurrent_74e95576-b134-4651-a7af-2c20bcf4c77c" xlink:href="kros-20250331.xsd#kros_SalesTaxReceivableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_kros_SalesTaxReceivableCurrent_74e95576-b134-4651-a7af-2c20bcf4c77c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_PrepaidExternalRDCostsCurrent_2e3f0601-b950-4a6a-8887-49192e0924c5" xlink:href="kros-20250331.xsd#kros_PrepaidExternalRDCostsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_726a39dd-bbea-401b-b650-026972707148" xlink:to="loc_kros_PrepaidExternalRDCostsCurrent_2e3f0601-b950-4a6a-8887-49192e0924c5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESScheduleofofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="kros-20250331.xsd#ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESScheduleofofAccruedExpensesandOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/ACCRUEDEXPENSESANDOTHERCURRENTLIABILITIESScheduleofofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_0bda8685-6df0-4ae8-9085-1ff77a301a18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_AccruedResearchAndDevelopmentCostsCurrent_56e2837e-8173-4490-985d-8541adad8662" xlink:href="kros-20250331.xsd#kros_AccruedResearchAndDevelopmentCostsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0bda8685-6df0-4ae8-9085-1ff77a301a18" xlink:to="loc_kros_AccruedResearchAndDevelopmentCostsCurrent_56e2837e-8173-4490-985d-8541adad8662" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_kros_AccruedManufacturingCostsCurrent_8d622756-98df-4294-ae9d-e5983ff6397a" xlink:href="kros-20250331.xsd#kros_AccruedManufacturingCostsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0bda8685-6df0-4ae8-9085-1ff77a301a18" xlink:to="loc_kros_AccruedManufacturingCostsCurrent_8d622756-98df-4294-ae9d-e5983ff6397a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_d038e737-ce8d-4191-bc15-f3aa49198a1e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0bda8685-6df0-4ae8-9085-1ff77a301a18" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_d038e737-ce8d-4191-bc15-f3aa49198a1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_f02a57f3-6d12-4b76-92fb-4560f55d38fd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0bda8685-6df0-4ae8-9085-1ff77a301a18" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_f02a57f3-6d12-4b76-92fb-4560f55d38fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_deb39753-92fe-4ae4-8fd5-d1f8fed298a7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0bda8685-6df0-4ae8-9085-1ff77a301a18" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_deb39753-92fe-4ae4-8fd5-d1f8fed298a7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/LOSSPERSHAREBasicandDilutedLossPerShareCalculationDetails" xlink:type="simple" xlink:href="kros-20250331.xsd#LOSSPERSHAREBasicandDilutedLossPerShareCalculationDetails"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/LOSSPERSHAREBasicandDilutedLossPerShareCalculationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_36cf3037-74ac-41a1-9892-e8702063c2ab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_0588e6b7-53d2-4d9b-8174-a6d0abd0e6c7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_36cf3037-74ac-41a1-9892-e8702063c2ab" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_0588e6b7-53d2-4d9b-8174-a6d0abd0e6c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_6f3d7a34-9346-49f0-8173-ad814a2caa86" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_36cf3037-74ac-41a1-9892-e8702063c2ab" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_6f3d7a34-9346-49f0-8173-ad814a2caa86" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.kerostx.com/role/SEGMENTREPORTINGDetails" xlink:type="simple" xlink:href="kros-20250331.xsd#SEGMENTREPORTINGDetails"/>
  <link:calculationLink xlink:role="http://www.kerostx.com/role/SEGMENTREPORTINGDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_99766684-e10c-4f98-af5a-faf139667d4f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_99766684-e10c-4f98-af5a-faf139667d4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeDividend_7a2a72a0-5eb3-4b2b-85f6-8337d2091e24" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InvestmentIncomeDividend"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_InvestmentIncomeDividend_7a2a72a0-5eb3-4b2b-85f6-8337d2091e24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_3513791a-9309-45f4-bd6e-6c8b2b5e8663" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_3513791a-9309-45f4-bd6e-6c8b2b5e8663" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_7d44c9d4-57b8-490e-99e2-406e8be0a072" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_Depreciation_7d44c9d4-57b8-490e-99e2-406e8be0a072" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CompensationExpenseExcludingCostOfGoodAndServiceSold_b82783c4-73aa-4c73-9709-75e2e6a81b4d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CompensationExpenseExcludingCostOfGoodAndServiceSold"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_CompensationExpenseExcludingCostOfGoodAndServiceSold_b82783c4-73aa-4c73-9709-75e2e6a81b4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_58bc3856-11d1-4509-97e3-15499ce51cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_58bc3856-11d1-4509-97e3-15499ce51cbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_979f3dca-7fd2-4c9a-b8c0-5b0260e7122d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_979f3dca-7fd2-4c9a-b8c0-5b0260e7122d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_74ef610c-5011-4742-af18-2785b26323e4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a454ffe8-9de4-4578-b07d-df3f78ae2964" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_74ef610c-5011-4742-af18-2785b26323e4" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
